| 摘要 |
PURPOSE: A melanocortin 4 receptor(MC4R) agonist is provided, thereby accelerating the function of the melanocortin 4 receiptor(MC4R), and consequently preventing and treating diseases associated with the MC4R such as obesity, penile erection disorder, diabetes and inflammation. CONSTITUTION: Compounds functioning as a melanocortin 4 receptor(MC4R) agonist are represented by formula(1), wherein A is hydrogen, COR1, CO2R1, SO2R1, SO2NHR1, SO2N(R1)2, PO(OR1)2, C1-C8-alkyl, (CH2)n-C5-C10-aryl or (CH2)n-C5-C10-heteroaryl in which R1 is hydrogen, C1-C8-alkyl, (CH2)n-C3-C7-cycloalkyl, (CH2)n-C5-C10-aryl or (CH2)n-C5-C10-heteroaryl, n is an integer of 0 to 7; B and C are independently hydrogen, C1-C8-alkyl, (CH2)n-C3-C7-cycloalkyl, (CH2)n-C5-C10-aryl, (CH2)n-C5-C10-heteroaryl, (CH2)n-C5-C10-heterocycle or (CH2)n-O(CH2)-C5-C10-aryl in which n is an integer of 1 to 7; D is hydrogen, C1-C8-alkyl, (CH2)n-C3-C7-cycloalkyl, (CH2)n-C5-C10-aryl, (CH2)n-C5-C10-heteroaryl, (CH2)n-C5-C10-heterocycle or (CH2)n-O(CH2)-C5-C10-aryl in which n is an integer of 1 to 7; E is C5-C10-alkyl or (CH2)m-C5-C7-cycloalkyl in which m is an integer of 0 to 2; and F is (CH2)m-C5-C10-heteroaryl or (CH2)m-C5-C10-heterocycle in which n is an integer of 0 to 2.
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