发明名称 |
High affinity ligand for p75 neurotrophin receptor |
摘要 |
The present invention provides an isolated protein comprising a pro-domain of a proneurotrophin, methods for producing the protein, and pharmaceutical compositions containing the isolated protein. The invention also provides a nucleic acid molecule which encodes the protein and a vector containing the nucleic acid molecule. The present invention further provides a method for cleaving a proneurotrophin protein to a mature neurotrophin. In addition, the invention relates to methods for inducing apoptosis in a cell of a mammal expressing p75 surface receptors or p75 and trk receptors. The methods include causing the p75 receptor to bind a pharmaceutical composition containing a pro-domain of a proneurotrophin or administering to the mammal an effective amount of a cleavage-resistant proneurotrophin and an inhibitor of trk activation. The invention also relates to a method for inhibiting apoptosis of a cell in a mammal by administering an effective amount of a molecule which inhibits binding of a proneurotrophin to a p75 receptor. Also provided, are kits and methods for screening a human for a condition associated with undesired apoptosis.
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申请公布号 |
US2003087804(A1) |
申请公布日期 |
2003.05.08 |
申请号 |
US20020155886 |
申请日期 |
2002.05.24 |
申请人 |
HEMPSTEAD BARBARA L;LEE RAMEE;TENG KENNETH K;KERMANI POUNEH |
发明人 |
HEMPSTEAD BARBARA L.;LEE RAMEE;TENG KENNETH K.;KERMANI POUNEH |
分类号 |
A61K38/00;A61K38/07;A61K38/08;A61K38/10;A61K38/12;A61K38/48;A61K38/55;C07K14/475;(IPC1-7):A01N37/18;C07K1/00;C07K14/00;C07K17/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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