发明名称 |
AN ANTINEOPLASTIC- DENDRITIC POLYMER DRUG DELIVERY SYSTEM |
摘要 |
Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared. The antineoplastic agent is encapsulated within the dendritic polymer using an ionic charge shunt mechanism, whereby, the antineoplastic agent interacts with the anionic functional groups on the surface of the dendritic polymer allowing the antineoplastic agent to be uptaken by the dendritic polymer through an association with the functional groups of the interior of the dendritic polymer. The antineoplastic dendritic polymer conjugates may be administered intravenously, orally, parentally, subcutaneously, intraarterially or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The antineoplastic dendritic polymer conjugates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, and reduced toxicity.
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申请公布号 |
WO03037383(A1) |
申请公布日期 |
2003.05.08 |
申请号 |
WO2001US48568 |
申请日期 |
2001.10.29 |
申请人 |
THE DOW CHEMICAL COMPANY;MALIK, NAVID;DUNCAN, RUTH;TOMALIA, DONALD, A.;ESFAND, ROSEITA |
发明人 |
MALIK, NAVID;DUNCAN, RUTH;TOMALIA, DONALD, A.;ESFAND, ROSEITA |
分类号 |
A61K47/34;A61K33/24;A61K47/48;A61P35/00;A61P35/02;C08G73/04;(IPC1-7):A61K47/48 |
主分类号 |
A61K47/34 |
代理机构 |
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地址 |
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