发明名称 |
Process for preparing 2-(4-chlorobenzolamino)-3[ (1h)-quinolinon-4-yl] propionic acid |
摘要 |
The invention relates to a novel method for preparing 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid, also known as Rebamipide represented by the formula I and useful for treatment of peptic ulcer from alkyl 2-(4-chlorobenzoylamino)-2-alkoxycarbonyl-3-[2(1H)-quinolinon-4-yl]propionate represented by the formula II in the presence of a base solution for hydrolysis and decarboxylation to remove a carboxyl group.
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申请公布号 |
US2003087930(A1) |
申请公布日期 |
2003.05.08 |
申请号 |
US20020240728 |
申请日期 |
2002.10.08 |
申请人 |
LEE BYOUNG-SUK;CHUN MYUNG-HEE |
发明人 |
LEE BYOUNG-SUK;CHUN MYUNG-HEE |
分类号 |
C07D215/24;A61K31/4704;A61P1/04;C07B61/00;C07C233/83;C07D215/14;C07D215/22;C07D215/227;(IPC1-7):C07D215/36;A61K31/47 |
主分类号 |
C07D215/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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