发明名称 |
Spiro-cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha converting enzyme (TACE) |
摘要 |
The present application describes novel spiro-cyclic beta-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-alpha converting enzyme (TACE), and/or aggrecanase inhibitors.
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申请公布号 |
US2003087882(A1) |
申请公布日期 |
2003.05.08 |
申请号 |
US20020096804 |
申请日期 |
2002.03.12 |
申请人 |
OTT GREGORY R;CHEN XIAO TAO;DUAN JINGWU;VOSS MATTHEW E |
发明人 |
OTT GREGORY R.;CHEN XIAO TAO;DUAN JINGWU;VOSS MATTHEW E. |
分类号 |
A61P1/04;A61P19/02;A61P35/04;C07D307/94;C07D317/72;C07D319/08;C07D339/06;C07D405/12;C07D407/12;C07D409/12;C07D417/12;C07D417/14;C07D491/04;(IPC1-7):A61K31/675;A61K31/55;A61K31/474;C07D471/10 |
主分类号 |
A61P1/04 |
代理机构 |
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地址 |
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