| 摘要 |
<p>A method for the selective hydrogenation of the 13,14-double bond in Series 2 prostaglandins which comprises forming the iodolactone (4) of the prostaglandin (3) by reaction with iodine in an aqueous, organic or aqueous/organic mixed solvent, followed by catalytic hydrogenation of the 13, 14-double bond of the iodolactone to give structure (5). The hydrogenation can be carried out with a heterogeneous or a homogeneous catalyst. Wherein R1 represents a substituted or unsubstituted alkyl, arylalkyl or aryloxy group. The two reactions can be carried out in sequence without isolation of the intermediate iodolactone (4). The free 9, 11 and 15 hydroxyl groups can be protected as their trimethylsilyl ethers. Mild aqueous acid work up gives the 13,14-dihydro analogue of the original prostaglandin (3).</p> |
