发明名称 |
Treatment protocol generation for diseases related to angiogenesis |
摘要 |
A computer-implemented method for determining an optimal treatment protocol for a disease related to angiogenesis, comprising creating an angiogenesis model including pro-angiogenesis and anti-angiogenesis factors. Effective vessel density (EVD) is incorporated as a factor regulating switching on and switching off of at least one component in the angiogenesis model. Effects of vasculature maturation and mature vessels destabilization are incorporated. Pro-angiogenesis and anti-angiogenesis factors, which can influence changes in state of a tissue are selected. Effects of drugs in the pro-angiogenesis and anti-angiogenesis factors are incorporated. A plurality of treatment protocols in a protocol space is generated. A best treatment protocol based on a pre-determined criteria.
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申请公布号 |
US2003088237(A1) |
申请公布日期 |
2003.05.08 |
申请号 |
US20020207772 |
申请日期 |
2002.07.31 |
申请人 |
AGUR ZVIA;ARAKELYAN LEVON;VAINSTEIN VLADIMIR |
发明人 |
AGUR ZVIA;ARAKELYAN LEVON;VAINSTEIN VLADIMIR |
分类号 |
A61K9/22;G01F1/32;G01F1/86;G01N33/74;G06N3/00;(IPC1-7):A61K9/22;A61B5/02 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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