| 摘要 |
The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the invention are represented by the following formula I: wherein the hatched segment represents an alpha bonds, the solid triangle represents a beta bond, the wavy segments represent a alpha or beta bond, dashed lines represent a double bond or a single bond, R<3> is heteroaryl or a substituted heteroaryl radical, R<1> and R<2> are independently selected from the group consisting of hydrogen or a lower alkyl radical having up to six carbon atoms, or a lower acyl radical having up to six carbon atoms, R is selected from the group consisting of CO2R<4>, CONR<4>2<, CH>2<OR?4>, CONR<4>SO2R<4>, P(O)(OR<4>) and wherein R<4> is selected from the group consisting of H, phenyl and lower alkyl having from one to six carbon atoms and n is O or an integer of from 1 to 4.
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