发明名称 |
ISOLATED PEPTIDE OF THE HEPATOCYTE GROWTH FACTOR AND ITS VARIANTS, PREPARATION METHOD AND THERAPEUTIC USE AS ANTI-ANGIOGENIC AGENTS |
摘要 |
The invention concerns a peptide substance selected from the group consistin g of: (i) peptide N derived from the HGF .alpha. chain and having an amino aci d sequence represented by SEQ ID No. 2, and (ii) its peptide variants derived from said peptide N sequence by suppression, substitution or addition of one or several amino acids. Said peptide N has an anti-angiogenic activity in accordance with a mechanism different from competitive fixation with HGF on the HGF-R receptor. The invention also concerns the therapeutic use and the preparation method of said peptide substance, as well as (i) the DNA fragmen t which expresses it, the plasmid containing said DNA and the bacteria containing said plasmid.
|
申请公布号 |
CA2465714(A1) |
申请公布日期 |
2003.05.08 |
申请号 |
CA20022465714 |
申请日期 |
2002.10.30 |
申请人 |
INSTITUT DES VAISSEAUX ET DU SANG |
发明人 |
MERKOULOVA-RAINON, TATIANA |
分类号 |
C12N15/09;A61K38/00;A61P17/02;A61P19/00;A61P27/00;A61P29/00;A61P35/00;C07K14/475;C12N1/21;C12N15/12;C12P21/02;(IPC1-7):C12N15/12;A61K38/18 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|