POLYMERIC IMMUNOGLOBULIN FUSION PROTEINS THAT TARGET LOW-AFFINITY FC gamma RECEPTORS
摘要
The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with Fc gamma R and which allow for the inclusion and targeting of a second protein domain to cells expressing Fc gamma R. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of Fc gamma R in autoimmune disorders.
申请公布号
WO02072608(A3)
申请公布日期
2003.05.08
申请号
WO2002US07365
申请日期
2002.03.11
申请人
UNIVERSITY OF CHICAGO;ARNASON, BARRY, G., W.;JENSEN, MARK, A.;WHITE, DAVID, M.
发明人
ARNASON, BARRY, G., W.;JENSEN, MARK, A.;WHITE, DAVID, M.