发明名称 |
METHOD OF SCREENING SUBSTANCE FOR PREVENTING OR TREATING DISEASES IN ASSOCIATION WITH IL-6 FAMILY CYTOKINE RECEPTOR MALFUNCTION |
摘要 |
<p>The invention provides a method of screening for substances preventing or treating diseases in association with IL-6 family cytokine receptor malfunction, which comprises using a transgenic mouse or a part thereof expressing a gp130 variant, wherein said gp130 variant comprises a substitution or a deletion of a tyrosine residue, which corresponds to the tyrosine residue at position 759 of human gp130 protein, or a substitution, an insertion or a deletion of one or more amino acid residues in a region comprising said tyrosine residue.</p> |
申请公布号 |
EP1308727(A1) |
申请公布日期 |
2003.05.07 |
申请号 |
EP20010953318 |
申请日期 |
2001.07.27 |
申请人 |
HIRANO, TOSHIO;SANTEN PHARMACEUTICAL CO., LTD. |
发明人 |
HIRANO, TOSHIO;HIBI, MASAHIKO;ISHIHARA, KATSUHIKO |
分类号 |
C07K14/715;C12N15/85;(IPC1-7):G01N33/50;A01K67/027;G01N33/15 |
主分类号 |
C07K14/715 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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