INDUCTION OF TOLERANCE TO A THERAPEUTIC POLYPEPTIDE

摘要

Liver-directed gene transfer can induce immunological tolerance to a polypeptide associated with the expression of a therapeutic nucleic acid Hepatic expression of a transgene induces tolerance to the expression product of the transgene, or t o post-translational product related to transgene expression, thereby ameliorating or eliminating the immune responses associated with gene therapy and protein replacement, respectively , independent of the genetic background of the subject.