Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates.
摘要
A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.
申请公布号
ZA200207206(B)
申请公布日期
2003.05.06
申请号
ZA20020007206
申请日期
2002.09.09
申请人
MOUNTAIN VIEW PHARMACEUTICALS, INC.
发明人
SAIFER, MARK, G., P.;SHERMAN, MERRY, R.;WILLIAMS, L., DAVID