发明名称 |
Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
摘要 |
Pharmaceutical compositions that have excellent storage stability even though they include a active component that is susceptible to degradation in an acidic environment are disclosed. The stabilized pharmaceutical composition of the invention includes a ring-opened 7-substituted-3,5-dihydroxyheptanoic or a ring-opened 7-substituted-3,5-dihydroxyheptenoic acid, or a pharmaceutically acceptable salt thereof, as an active component and a stabilizing effective amount of at least one amido-group containing polymeric compound or at least one amino-group containing polymeric compound, or combination thereof; wherein the stabilized pharmaceutical composition does not contain a stabilizing effective amount of another stabilizer or a combination of other stabilizers. The pharmaceutical composition may optionally include one or more pharmaceutically acceptable excipients such as a filler, a disintegrating agent and one or more lubricants such as magnesium stearate to aid compression where a tablet dosage form is desired.
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申请公布号 |
US6558659(B2) |
申请公布日期 |
2003.05.06 |
申请号 |
US20010829026 |
申请日期 |
2001.04.09 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
FOX MICHAEL;DOROSSIEV IVO |
分类号 |
A61K9/20;A61K9/26;(IPC1-7):A61K31/74;A61K9/16;A61K9/48;A61K31/425 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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