发明名称 |
Polyamide-alkylator conjugates and related products and method |
摘要 |
The present invention is based on the surprising and unexpected discovery of new and useful polyamide-alkylator conjugates. As a result of their DNA binding properties, polyamides deliver reactive moieties for covalent reaction at specific DNA sequences and thereby inhibit DNA-protein interactions. Thus, site specific alkylation of DNA is a useful tool to regulate gene expression. In addition to competing with transcription factors or promoters, the conjugates of the present invention will be used to target a gene's coding region. This will allow using synthetic chemistry to create a new class of gene specific "knockout" reagents which will be useful in biological disciplines.
|
申请公布号 |
US6559125(B1) |
申请公布日期 |
2003.05.06 |
申请号 |
US20010772315 |
申请日期 |
2001.01.26 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
DERVAN PETER B.;WURTZ NICHOLAS;CHANG AILEEN |
分类号 |
A61K47/48;(IPC1-7):A61K38/00;A01N43/04;C12Q1/68;C07H21/00 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|