发明名称 |
Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
摘要 |
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
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申请公布号 |
US6558942(B1) |
申请公布日期 |
2003.05.06 |
申请号 |
US19980073538 |
申请日期 |
1998.05.06 |
申请人 |
THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
KHOSLA CHAITAN;KAO CAMILLA M. |
分类号 |
C07B61/00;C07D309/36;C07D311/92;C07D323/00;C07D407/06;C07H17/08;C12N9/00;C12N15/52;C12P7/26;C12P17/06;C12P17/08;C12P17/16;(IPC1-7):C12Q1/00;C12P1/00 |
主分类号 |
C07B61/00 |
代理机构 |
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