发明名称 |
6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
摘要 |
The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
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申请公布号 |
US6559152(B2) |
申请公布日期 |
2003.05.06 |
申请号 |
US20010794825 |
申请日期 |
2001.02.27 |
申请人 |
DUPONT PHARMACEUTICALS COMPANY |
发明人 |
MARKWALDER JAY A.;SEITZ STEVEN P.;SHERK SUSAN R. |
分类号 |
A61K31/519;A61K31/5377;A61K31/55;A61P35/00;A61P43/00;C07D471/04;C07D487/04;(IPC1-7):A61K31/519;A61K31/44;C07D487/00;C07D237/26;C07D471/02 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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