| 发明名称 |
Process for the preparation of optically active (R or S)-1-(4-methoxy-benzyl)-1,2,3,4,5,6,7,8-octahydro-isoquinolines |
| 摘要 |
<p>Preparation of optically active R- or S- 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline salts of formula (I) comprises asymmetric hydrogenation of the corresponding 3,4,5,6,7,8-hexahydro-salts of formula (II) using an optically active diphosphine complex of iridium. HX = HBF4, H2SO4, HPF6, HBr, HI, HCl, HSbF6, HClO4, (1-8Calkyl)-SO3H, picric acid, formic acid, lower-alkyl carboxylic acid, aryl carboxylic acid or dicarboxylic acid.</p> |
