Methods of antibiotic coating of objects having interconnected microcavities and the uses thereof

摘要

Production of an antibiotic coating on a porous body comprises impregnation with a solution of gentamicin dodecyl sulfate or sulfonate (I) and evaporation of the solvent, where (I) has 1-5 dodecyl sulfate or sulfonate groups per gentamicin molecule. Independent claims are also included for: (1) a process for producing an antibiotic coating on a porous body, comprising impregnation with a solution of ciprofloxacin or moxifloxacin dodecylbenzyl sulfonate, ciprofloxacin or moxifloxacin dodecyl sulfate and/or clindamycin, tetracyline, lincosamine, chlortetracycline, oxytetracyline, demethylchlortetracycline, methacycline, doxycycline, rolitetracycline and minocycline dodecyl sulfate and/or sulfonate and evaporation of the solvent; (2) a body with pores (interconnecting microcavities) coated with (I) or with ciprofloxacin dodecylbenzyl sulfonate and/or clindamycin, tetracyline, lincosamine, chlortetracycline, oxytetracyline, demethylchlortetracycline, methacycline, doxycycline, rolitetracycline and minocycline dodecyl sulfate and/or sulfonate.