发明名称 |
TREATMENT OF HYPERTENSION WITH COMPOUNDS THAT INHIBIT THE DESTRUCTION OF ENKEPHALINS OR ENDORPHINS |
摘要 |
A new class of anti-hypertensive agent is provided by substances that inhibit the breakdown of the endogenous substances, the enkephalins and/or the endorphins. The anti-hypertensive effect of an enkephalin breakdown inhibitor is greatly enhanced by being combined with a beta adrenergic blocking agent, herein designated as beta blocker. Specifically, D-phenylalanine, en enkephalin breakdown inhibitor when used alone produces excellent blood pressure lowering in animals and man. Use of a combination of D-phenylalanine and the beta blocker propranolol provides a greatly enhanced anti-hypertensive effect in the spontaneously hypertensive rat (SHR). Blood pressure lowering by D-phenylalanine, or the latter combination, is very long lasting in the SHR and man. If the blood pressure of the rat or human is normal, D-phenylalanine has little or no effect on blood pressure. The hypotensive effect of D-phenylalanine is prevented by pretreating the SHR with naloxone or naltrexone which are specific antagonists of enkephalins or endorphins. |
申请公布号 |
EP1158972(A4) |
申请公布日期 |
2003.05.02 |
申请号 |
EP20000903252 |
申请日期 |
2000.01.12 |
申请人 |
EHRENPREIS, SEYMOUR;BLUM, KENNETH |
发明人 |
EHRENPREIS, SEYMOUR;BLUM, KENNETH |
分类号 |
A61K31/00;A61K31/195;A61K31/198;A61K31/40;A61K31/401;A61K31/70;A61K33/24;A61K45/06 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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