PYRIMIDONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

The invention provides novel pyrimidone compounds exhibiting excellent antagonism against adenosine receptors A1, A2A, and A2B receptors, particularly, compounds represented by the general formula I, salts thereof, or solvates of both: I wherein R1 and R2 are each independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, a 5- to 14-membered nonaromatic heterocyclic group, a C6-14 aromatic hydrocarbon group, a 5- to 14-membered aromatic heterocyclic group, C1-6 acyl, or C1-6 alkylsulfonyl R3 is hydrogen, C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl R4 is a C6-14 aromatic hydrocarbon group a 5- to 14-membered aromatic heterocyclic group, or a 5- to 14-membered nonaromatic heterocyclic group having at least one unsaturated bond and R5 is a C6-14 aromatic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group with the proviso that every group except hydrogen may be substituted.