HOMEODOMAIN-INTERACTING PROTEIN KINASES AND THE USE OF THE SAME FOR INFLUENCING CELL DIVISION AND CELL PROLIFERATION

摘要

The invention relates to the use of homeodomain-interacting protein kinases (HIPKs), especially HIPK2, and the nucleic acid sequences coding for the same, for influencing cell division and cell proliferation, and especially the use thereof in methods for diagnosing or treating diseases associated with anomalous or excessive cell proliferation e.g. tumour diseases. The invention also relates to the use of HIPKs, especially HIPK2, the nucleic acid sequences coding for the same and specific bonding partners thereof, for identifying and/or producing substances which can inhibit or stimulate cell division or cell growth or influence the same in other ways. The invention especially relates to a human HIPK2 and derivatives and fragments thereof, the nucleic acid sequences coding for the same, and antibodies and other specific bonding partners of the human HIPK2 and the nucleic acid sequence coding for the same.