COMPOSITIONS AND METHODS RELATING TO THE DAPTOMYCIN BIOSYNTHETIC GENE CLUSTER
摘要
The invention provides nucleic acid molecules comprising all or a part of a daptomycin biosynthetic gene cluster. The daptomycin biosynthethic gene cluster may be derived from Streptomyces, preferably from S. roseosporus. The invention also provides other nucleic acid molecules from S. roseosporus. The invention further provides polypeptides encoded by the nucleic acid molecules, antibodies that specifically bind to the polypeptides, and methods of using the nucleic acid molecules, polypeptides and antibodies to produce daptomycin and other compounds.
申请公布号
WO02059322(A9)
申请公布日期
2003.05.01
申请号
WO2001US32354
申请日期
2001.10.17
申请人
CUBIST PHARMACEUTICLAS, INC.;MIAO, VIVIAN, PAK, WOON;BRIAN, PAUL;BALTZ, RICHARD, H.;SILVA, CHRISTOPHER, J.
发明人
MIAO, VIVIAN, PAK, WOON;BRIAN, PAUL;BALTZ, RICHARD, H.;SILVA, CHRISTOPHER, J.