发明名称 |
Fc fusion proteins of human erythropoietin with increased biological activities |
摘要 |
Fc fusion proteins of human EPO with increased biological activities relative to rHuEPO on a molar basis are disclosed. The HuEPO-L-vFc fusion protein comprises HuEPO, a flexible peptide linker of about 20 or fewer amino acids, and a human IgG Fc variant. The Fc variant is of a non-lytic nature and shows minimal undesirable Fc-mediated side effects. A method is also disclosed to make or produce such fusion proteins at high expression levels. Such HuEPO-L-vFc fusion proteins exhibit extended serum half-life and increased biological activities, leading to improved pharmacokinetics and pharmacodynamics, thus fewer injections will be needed within a period of time. |
申请公布号 |
US2003082749(A1) |
申请公布日期 |
2003.05.01 |
申请号 |
US20010932812 |
申请日期 |
2001.08.17 |
申请人 |
SUN LEE-HWEI K.;SUN BILL N. C.;SUN CECILY R. Y. |
发明人 |
SUN LEE-HWEI K.;SUN BILL N. C.;SUN CECILY R. Y. |
分类号 |
A61K38/00;C07K14/505;C12P21/04;(IPC1-7):C12P21/04;C12N5/06;C07K16/46 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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