发明名称 |
TREATMENT PROTOCOL GENERATION FOR DISEASES RELATED TO ANGIOGENESIS |
摘要 |
A computer-implemented method for determining an optimal treatment protocol for a disease related to angiogenesis, comprising creating an angiogenesis model including pro-angiogenesis and anti-angiogenesis factors. Effective vessel density (EVD) is incorporated as a factor regulating switching on and switching off of at least one component in the angiogenesis model. Effects of vasculature maturation and mature vessels destabilization are incorporated. Pro-angiogenesis and anti-angiogenesis factors, which can influence changes in state of a tissue are selected. Effects of drugs in the pro-angiogenesis and anti-angiogenesis factors are incorporated. A plurality of treatment protocols in a protocol space is generated. A best treatment protocol based on a pre-determined criteria. |
申请公布号 |
WO03036410(A2) |
申请公布日期 |
2003.05.01 |
申请号 |
WO2002IB04725 |
申请日期 |
2002.10.24 |
申请人 |
OPTIMATA LTD.;AGUR, ZVIA;ARAKELYAN, LEVON;VAINSTEIN, VLADIMIR |
发明人 |
AGUR, ZVIA;ARAKELYAN, LEVON;VAINSTEIN, VLADIMIR |
分类号 |
A61K9/22;G01F1/32;G01F1/86;G01N33/74;G06N3/00 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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地址 |
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