METHOD FOR ORAL DRUG DELIVERY

摘要

A novel mucoadhesive patch system for drug delivery comprising an impermeable backing layer, a drug reservoir and a mucoadhesive layer. After introduction into the gastrointestinal tract, the mucoadhesive layer of the patch sticks to the lumenal wall, then the drug releases from the reservoir in a unidirectional way through the mucoadhesive layer into intestine mucosa. The patch system and method of drug delivery is advantageous in enhancing bioavailabilities of poorly absorbed drugs such as polar molecules or bioactive peptides and proteins.