发明名称 ANTISENSE OLIGODEOXYNUCLEOTIDES REGULATING EXPRESSION OF TNF ALPHA
摘要 A synthetic nuclease resistant antisense oligodeoxynucleotide capable of selectively modulating expression of human tumor necrosis factor-alpha by targeting exon sequences flanking donor splice sites, thereby regulating expression of TNF-alpha in a patient in need of such therapy is provided. In an embodiment either AS-ODN having the sequence set forth in SEQ ID No:4 or SEQ ID No:6 or a combination thereof can be used. The AS-ODN is administered either as the active ingredient in a pharmaceutical composition or by utilizing gene therapy techniques as an expression vector.
申请公布号 US2003083275(A1) 申请公布日期 2003.05.01
申请号 US19990439429 申请日期 1999.11.15
申请人 POWER CHRISTOPHER;MAYNE MICHAEL B. 发明人 POWER CHRISTOPHER;MAYNE MICHAEL B.
分类号 A61K31/70;A61K38/00;A61K48/00;C07H21/00;C12N15/113;C12N15/28;(IPC1-7):A61K48/00;C07H21/04 主分类号 A61K31/70
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