NOVEL PREPARATION OF SELECTIVE CYCLOOXYGENASE II INHIBITORS

摘要

A clear, stable novel phrmaceutical preparation of selective cyclooxygenase II inhibitors (COX 2) inhibitors in the parenteral form for the treatment of pain & inflammatory conditions arising because of cyclooxygenase-2 activity. In particular the pharmaceutical preparation of COX 2 inhibitors comprise of selective active COX 2 inhibitors selected from Celeoxib, Rofecoxib and their analogues dissolved in a selective isosorbide type solvent of general formula (I) where R1 and R2 are hydrogen or alkyl chains containing 1 - 3 carbons or acetate group. Also disclosed is a simple and cost effective process of manufacture of the above novel pharmaceutical preparation.