发明名称 |
Optically active 3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists |
摘要 |
The present invention relates to optically active 3-[(2-piperazinylphenyl)methyl]-1-[4(trifluoromethylphenyl]-2-pyrrolidinones and pharmaceutically acceptable salts thereof, to processes for their preparation, to isotopically-labeled analogs thereof, to pharmaceutical compositions comprising them and to their medicinal use as selective antagonists of the 5-HT1D rector. The compounds of the invention are useful in treating depression, obsessive-compulsive disorder (OCD) and diseases, disorders or conditions for which a 5-HT1D receptor selective antagonist is therapeutically indicated.
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申请公布号 |
US2003083337(A1) |
申请公布日期 |
2003.05.01 |
申请号 |
US20020215910 |
申请日期 |
2002.08.09 |
申请人 |
HOWARD HARRY R.;CARON STEPHANE;ADAM MAVIS D. |
发明人 |
HOWARD HARRY R.;CARON STEPHANE;ADAM MAVIS D. |
分类号 |
C07D207/27;A61K31/135;A61K31/496;A61K45/00;A61P1/00;A61P1/14;A61P3/04;A61P5/00;A61P15/00;A61P25/00;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P43/00;C07D207/26;(IPC1-7):A61K31/496;C07D43/02 |
主分类号 |
C07D207/27 |
代理机构 |
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代理人 |
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地址 |
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