IMIDAZOPYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS

摘要

This invention provides a compound of the formula (I), or the pharmaceutically acceptable salts thereof wherein R<1> is hydrogen, halo or alkyl; R<2> and R<3> are independently hydrogen, alkyl, alkenyl, alkynyl, aminoalkyl or hydroxyalkyl; or R<2> and R<3> taken together with the nitrogen atom to which they are attached may form hetrocyclic; R<4> is hydrogen, halo, acyl, amino, amido, aryl, arylalkyl, or heteroaryl; R<5> is hydrogen, halo, alkyl, alkenyl, alkynyl, acyl, amino, amido, aryl, arylalkyl, or heteroaryl; R<6> is hydrogen, alkyl or alkoxyalkyl; X is NR<9> wherein R<9> is hydrogen or alkyl; and Y is (CR<7>R<8>) wherein n is an integer from 0 to 5. These compounds have 5-HT4 receptor binding activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, Functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans. This invention also provides a pharmaceutical composition comprising the above compound.