INHIBITORS OF DIPEPTIDYL PEPTIDASE IV

摘要

Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R<1> is H or CN, X<1> is O, S, CH2, CHF, CF2, CH(CH3), C(CH3)2 or CH(CN), and b is 1 or 2. G<1> is H or a group according to the formula -CH2-X<2>-(CH2)a-G<3> and G<2> is H or a group according to the formula -CH2-(CH29a-G<3>, provided that one of G<1> and G<2> is H and the other is not H. X<2> is O, S, or CH2, and a is 0, 1 or 2, provided that when a is 1 then X2 is CH2. G<3> is a group according to one of general formulae 2-4., where the variables have meaning given in the description. The compounds are useful in the treatment of i.a. type 2 diabetes and impaired glucose tolerance.