MORPHINE-6-GLUCURONIDE SYNTHESIS

摘要

The invention provides a novel method for synthesising M6G, and intermediates therefor. In order to synthesise M6G the major problem to overcome is to obtain the glycoside linkage with very high beta-selectivity since prior methods produce the alpha-anomer. The invention provides a method for the preferential synthesis of the beta-anomer of M6G which includes the step shown in Scheme 6 wherein use of DMAP is optional.