ANTI-RESTENOSIS AGENT

摘要

An anti-restenosis agent comprises a phosphorothioate-modified oligonucleotide wherein the oligonucleotide includes at least one hairpin loop and a TG sequence. The hairpin loop preferably has the sequence CAG CGA AGC. Especially preferred oligonucleotides are ones whiich include a sequence selected from TGGGG TGGGG T GGGGT GGGGT CAG CGA AGC and TTGGG TTGGG T GGGTT GGGTT CAG CGA AGC. The anti-restenosis agent may be used as or in a coating on a device for implantation into the body, for instance a stent.