BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS KDR PROTEIN KINASE INHIBITORS

摘要

The invention concerns novel products of formula (IA), wherein: A represents an optionally substituted cyclic or bicyclic saturated heterocycle, in particular pyrazole or imidazole, optionally substituted; A1, A2, A3 and A4, identical or different, are in particular selected among hydrogen, halogen, hydroxyl, alkyl and alkoxy, nitro, cyano, phenyl, phenoxy, free carboxy, salified, esterified by an alkyl radical or amidified to form CONA6A7 cyclized or not, with two among A1b, A2b, A3b and A4b capable of forming with the benzimidazole radical a cycle containing one or several heteroatoms; A5 represents hydrogen or alkyl, said products being in all isomeric forms and the salts as medicines in particular KDR inhibitors.