发明名称 |
MODULATION OF IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS BY OPTIMAL PRESENTATION OF 5' ENDS |
摘要 |
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating a immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3' ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5' end.
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申请公布号 |
WO03035836(A2) |
申请公布日期 |
2003.05.01 |
申请号 |
WO2002US33756 |
申请日期 |
2002.10.22 |
申请人 |
HYBRIDON INC. |
发明人 |
AGRAWAL, SUDHIR;KANDIMALLA, EKAMBAR, R.;YU, DONG;BHAGAT, LAKSHMI |
分类号 |
A61K31/7105;A61K31/711;A61K31/7115;A61K31/712;A61K31/7125;A61K38/00;A61K39/00;A61P11/00;A61P11/06;A61P35/00;A61P37/02;A61P37/04;A61P37/08;C07H21/00;C07H21/02;C07H21/04;C12N15/117;(IPC1-7):C12N/ |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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