| 摘要 |
The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of formula wherein the substituents have the meanings listed in the description, which are useful in the treatment of obesity, overweight condition, hyperlipidaemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid diseases, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression and osteoporosis. The present invention also provides methods, pharmaceutical compositions and kits for treating such diseases and disorders. 27 claims
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