| 摘要 |
The invention concerns a method for producing organic compounds by reacting aliphatic halides (I) with metal lithium, so as to form a lithium alkyl (II), then by subsequent or simultaneous deprotonation of a secondary amine (III), so as to form a lithiated amide base (IV), said step being followed by another reaction with aromatic compounds of formula (V), so as to form the corresponding lithium aromatic compound (VI). Step 1: producing the lithium base. Step 2: producing the amide base. Step 3: deprotonation lithiation. (EQUATION 1) wherein the substituents R, R<sb>1-5</sb>, X<sb>1-5</sb>, L<sb>1</sb> and L<sb>2</sb> represent the following: R represents methyl, primary, secondary or tertiary alkyl radicals having up to 12 carbon atoms, which are optionally substituted by a radical from the following group: {phenyl, substituted phenyl, aryl, heteroaryl, alkoxy, dialkylamino, alkylthiol, substituted alkyl, substituted or unsubstituted cycloalkyl having 3 to 8 carbon atoms; Hal = fluorine, chlorine, bromine or iodine; the radicals X<sb>1-5</sb> represent independently of one another carbon or one or several X<sb>1-5</sb> R<sb>1-5</sb> groups may represent nitrogen or in each case two adjacent X<sb>1-5</sb> R<sb>1-5</sb> radicals may together represent O, S, NH, or NR', wherein R' represents C<sb>1</sb>-C<sb>5</sb> alkyl, SO<sb>2</sb>-phenyl, SO<sb>2</sb>-p-tolyl or benzoyl; the radicals R<sb>1-5</sb> represent substituents from the group {hydrogen, methyl, CF<sb>3</sb>, cyclic or acyclic primary, secondary or tertiary alkyl radicals having up to 12 carbon atoms wherein optionally one or several atoms are substituted by F, optionally substituted cyclic or acyclic alkyl groups, alkoxy, dialkylamino, alkylamino, arylamino, diarylamino, phenyl, substituted phenyl, alkylthio, diarylphosphino, dialkylphosphino, dialkyl- or diarylaminocarbonyl, monoalkyl- or monoarylaminocarbonyl, CO<sb>2</sb>, hydroxyalkyl, alkoxyalkyl, heteroaryl, CN, fluorine or chlorine} or in each case two adjacent X<sb>1-5</sb> R<sb>1-5</sb> radicals optionally form together an aromatic or aliphatic cyclic compound; the radicals L1 and<sb> </sb>L2, identical or different, independently of each other represent hydrogen, provided that the two radicals L1 and L2 do not simultaneously represent hydrogen, or represent methyl, primary, secondary and tertiary alkyl radicals having 2 to 12 carbon atoms, which are optionally substituted by a radical from the following group {phenyl, substituted phenyl, aryl, heteroaryl, alkoxy, dialkyamino, alkylthio}, or substituted alkyl, substituted or unsubstituted cycloalkyl having 3 to 8 carbon atoms, trimethylsilyl, trialkylsilyl, phenyldialkylsilyl or diphenylalkylsilyl.
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