Sulfonamide lactam inhibitors of FXa and method

摘要

Sulfonamide lactams of the following formulawherein X, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and R8 are as described herein, are provided which inhibitors of Factor Xa and are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.