发明名称 Azabicyclic amine derivatives and their use as therapeutic agents
摘要 The present invention relates compounds of the formula (I):whereinX represents hydrogen or a C1-4alkyl group optionally substituted by a hydroxy group;Y represents hydrogen, C1-6alkyl or C3-7cycloalkyl;Z is -CR9R10CH2- or -CH2CR9R10-;R represents hydrogen, fluorine, hydroxy, C1-6alkyl or C1-6alkoxy;and R1, R2, R3, R4, R5 and R6 are as defined herein.The compounds are of particular use in the treatment of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
申请公布号 US6555552(B2) 申请公布日期 2003.04.29
申请号 US20020113965 申请日期 2002.04.01
申请人 MERCK SHARP & DOHME LTD. 发明人 KULAGOWSKI JANUSZ JOZEF;RAUBO PIOTR ANTONI;THOMSON CHRISTOPHER GEORGE
分类号 A61M15/00;C07C45/00;C07C45/29;C07C45/40;C07D451/02;C07D451/04;C07D451/06;G01F11/00;(IPC1-7):A61K31/46;C07D45/02 主分类号 A61M15/00
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