发明名称 |
Method of producing catalytic antibodies in a human |
摘要 |
A method for producing catalytic antibodies to a specific antigen in a non-human subject. The method comprises administering to the non-human subject a growth factor precursor comprising an antigen capable of interacting with a B cell bound catalytic antibody. The antigen is fused to at least one B cell surface molecule binding portion which is flanked by one or more blocking groups that prevent the binding portion from interacting with a surface molecule until the blocking groups are cleaved by a target catalytic antibody. The administration is conducted for a time and under conditions for the antigen to be cleaved and for the remainder of the molecule to induce B cell mitogenesis. |
申请公布号 |
NZ515603(A) |
申请公布日期 |
2003.04.29 |
申请号 |
NZ19980515603 |
申请日期 |
1998.09.18 |
申请人 |
FRANK KOENTGEN |
发明人 |
KOENTGEN, FRANK;SUESS, GABRIELE;TARLINTON, DAVID MATTHEW;TREUTLEIN, HERBERT RUDOLF |
分类号 |
C07K16/18;C12N9/00;C12N15/19;(IPC1-7):C07K14/475;C07K16/00;C12P21/00;C07K16/22 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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