| 发明名称 |
COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES, TAXANES AND/OR ANTIMETABOLITES. |
| 摘要 |
<p>The present invention provides the combined use of acryloyl distamycin derivatives, in particular agr;-bromo- and -agr;-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, antimicrotubule agents and/or an antimetabolites. Also provided is the use of the said combination in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.</p> |
| 申请公布号 |
MXPA02012165(A) |
申请公布日期 |
2003.04.25 |
| 申请号 |
MX2002PA12165 |
申请日期 |
2001.06.20 |
| 申请人 |
PHARMACIA ITALIA S.P.A. |
发明人 |
GERONI, MARIA, CRISTINA, ROSA |
| 分类号 |
C07D305/14;A61K31/337;A61K31/40;A61K31/4025;A61K31/4155;A61K31/4178;A61K31/475;A61K31/505;A61K31/513;A61K31/519;A61K31/565;A61K31/7064;A61K31/7068;A61K45/06;A61P35/00;C07D207/456;C07D519/04 |
主分类号 |
C07D305/14 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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