发明名称 SUBSTITUTED 1 AMINOALKYL LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS.
摘要 <p>This invention relates to compounds which are generally muscarinic M2 M3 receptor antagonists and which are represented by Formula (1) wherein one of X, Y, or Z is independently S , O , or gt; N R4, the others are CH2 ; (p) is an integer from 0 to 3 inclusive; m is an integer from 0 to 3 inclusive; n is an integer from 1 to 6 inclusive; R3 is (C1 6) alkyl, (C1 6) alkenyl, (C 1 6) alkynyl or cycloalkyl; and R1, R2 and R3 are hydrogen or specified substituents. These compounds are useful for treating diseases associated with smooth muscle disorders.</p>
申请公布号 MXPA02011417(A) 申请公布日期 2003.04.25
申请号 MX2002PA11417 申请日期 2001.05.17
申请人 F. HOFFMANN LA ROCHE AG 发明人 MADERA, ANN, MARIE
分类号 A61K31/33;A61K31/395;A61K31/495;A61K31/496;A61K31/535;A61K31/5377;A61K31/55;A61K31/551;A61K31/553;A61P1/00;A61P1/06;A61P11/00;A61P11/06;A61P13/02;A61P13/06;A61P15/00;A61P21/00;A61P21/02;A61P43/00;C07D207/26;C07D207/27;C07D211/76;C07D223/10;C07D225/02;C07D239/10;C07D241/08;C07D243/04;C07D243/08;C07D265/10;C07D267/06;C07D267/10;C07D267/22;C07D279/06;C07D401/06;C07D401/12;C07D403/06;C07D403/12;C07D405/06;C07D405/12;C07D405/14;C07D409/06;C07D409/12;C07D409/14;C07D411/12;C07D413/06;C07D413/12;C07D413/14;C07D417/06;C07D417/12;C07D417/14 主分类号 A61K31/33
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