NUCLEIC ACIDS ENCODING A NOVEL REGULATOR OF G PROTEIN SIGNALING, RGS18, AND USES THEREOF.

摘要

The present invention relates to nucleic acids that encode novel Regulator of G protein Signaling RGS18 polypeptides. RGS18 polypeptides are abundantly expressed in platelets and comprise a novel RGS domain (RGS18 domain). The present invention also relates to RGS18 polypeptides. The invention also relates to means for the detection of RGS18 nucleic acids and RGS18 polypeptides. The invention also relates to methods for the detection of activators or inhibitors of RGS18 polypeptides. Finally, the present invention relates to methods of prevention and or treatment of disorders or conditions associated with platelet activation dysfunction.