PYRROLIDINE AND PIPERIDINE DERIVATIVES AND THEIR USE FOR THE TREAMENT OF NEURODEGENERATIVE DISORDERS.

摘要

The invention relates to compounds of formula (I) wherein Ar1 is pyridyl or phenyl, substituted by hydroxy, lower alkyl, halogen, amino, nitro, benzyloxy or lower alkoxy lower alkoxy, or is the group (a) wherein Z1 is a five membered heterocyclic ring, which contains one or two heteroatoms, selected from N or O; R1 is hydrogen, hydroxy or an oxo group; Ar2 is pyridyl or phenyl, optionally substituted by hydroxy, lower alkyl, halogen, amino, nitro, benzyloxy or lower alkoxy lower alkoxy, or is the group (b) wherein Z2 is a five or six membered ring, which optionally contains one or two heteroatoms, selected from N or O; and Q is S , S(O) or S(O)2 ; X is a bond, CH(OH) or (CH2)n ; A is a bond or (CHR)m ; R is hydrogen, halogen or hydroxy, independently from each other if m is 2 or 3; Y is (CR2)m , O , C=C , Cequiv;C , piperidin 1 yl, pyrrolidin 1yl or C4 C6 cycloalkyl, which rings are optionally substituted by hydroxy; B is a bond, O or (CHR)m; n is 1 or 2; and m is 1 to 3 and pharmaceutically acceptable acid addition salts thereof with the exception of compounds, wherein A and B are simultaneously a bond and Y is CHR . The compounds may be used in the treatment of neurodegenerative diseases.