发明名称 |
COMPOSITIONS AND METHODS FOR TREATING CELLULAR RESPONSE TO INJURY AND OTHER PROLIFERATING CELL DISORDERS REGULATED BY HYALADHERIN AND HYALURONANS |
摘要 |
The present invention provides compositions and methods for treating disorders associated with a response-to-injury process or proliferating cells in a mammal. These tissue disorders are associated with a novel cellular phenotype designated as "transition cells" which are described herein, This cellular phenotype is characterized in having an activated erk kinase signaling activity, a stimulated AP-l binding activity, and at least one characteristic selected from the group consisting of: (a) increased podosome formation, (b) increased flux of intracellular or extracellular hyaluronans or hyaladherins, (c) increased expression of a hyaladherin, (d) an inability to form focal adhesions, (e) increased metalloproteinase activity, and (f) increased expression of a hyaladherin. Example of disorders include multiple sclerosis, diabetes mellitus and restenosis. The methods provided herein include administering to the mammal, an effective amount of a composition that alters the activity of transition molecules within a cell Transition molecules are shown to be comprised of hyaladherins, hyaluronans and associated molecules that regulate the transitional phenotype. A novel cell culture comprising transition cells is also provided, as well as compositions comprising particular peptides, polypeptides, and antibodies that affect the transitional phenotype. |
申请公布号 |
WO03033535(A2) |
申请公布日期 |
2003.04.24 |
申请号 |
WO2002CA01563 |
申请日期 |
2002.10.15 |
申请人 |
TRANSITION THERAPEUTICS INC.;CRUZ, TONY;PASTRAK, ALEKSANDRA;TURLEY, EVA, A. |
发明人 |
CRUZ, TONY;PASTRAK, ALEKSANDRA;TURLEY, EVA, A. |
分类号 |
A61K38/17;A61P3/10;A61P9/10;A61P25/02;A61P37/00;C07K14/00;C07K14/47;C07K16/18 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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