| 摘要 |
Adenosine deaminase is a purine catabolic enzyme, which catalyzes the deamination of adenosine and 2<,>-deoxyadenosine to inosine and 2<,>-deoxyinosine, respectively. A deficiency of adenosine deaminase causes severe immunodeficiency disease. Current therapies for adenosine deficiency include bone marrow transplantation and enzyme replacement therapy. Zmim19 is a new human adenosine deaminase, which has uses in therapy, diagnostics, and industry. |
