AMINOBORANE ACID DERIVATIVE AND PROTEASOME INHIBITORY DRUG CONTAINING THE SAME
摘要
A novel aminoborane acid derivative represented by the general formula (1): (1) (wherein X is a group of the general formula (2), (3), or (4); (2) (3) (4) Y is the group of the formula (5) or (6); (5) (6) R<sp>1</sp> and R<sp>2</sp> are the same or different and each is C<sb>3−6</sb> alkyl or C<sb>1−6</sb> alkyl substituted by phenyl; Z<sp>1</sp> is oxygen or sulfur; Z<sp>2</sp> is hydrogen, methoxy, or halogeno; and m is 1 or 2), which has proteasome inhibitory activity. The compound having proteasome inhibitory activity is useful as an immunosuppressant, anti−inflammatory agent, antiallergic, remedy for autoimmune diseases, remedy for chronic inflammatory diseases such as inflammatory bowel diseases (ulcerative colitis and Crohn's disease), anticancer agent, or remedy for nerve degeneration diseases.
