New 3-acylamino-cyclopentanopyrazole derivatives, useful for treating e.g. cancer and viral infections, inhibit cyclin-dependent kinase

摘要

3-acylamino-cyclopentanopyrazole derivatives (I), their tautomers, isomers and salts are new. 3-acylamino-cyclopentanopyrazole derivatives of formula (I), their tautomers, isomers and salts are new. R<1> = 1-6C alkyl, 2-6C alkenyl or alkynyl, 1-6C alkoxy or alkylthio, 3-12C (hetero)cycloalkyl or (hetero)cycloalkenyl, or (hetero)aryl, optionally with one or more substituents; R<2>, R<3> = H, 1-6C alkyl, 2-6C alkenyl or alkynyl, or 1-6C alkoxy, optionally with one or more, same or different substituents; R<4>, R<5> = R<2>, or together form a carbonyl or a 5 or 6-membered acetal with 2 O or S atoms or 1 O and 1 N or S, optionally substituted by 1-6C alkyl, or together they form 3-12C cycloalkyl or cycloalkenyl, optionally with one or more substituents; R<6>, R<7> = H, 1-6C alkyl, 2-6C alkenyl or alkynyl, optionally with one or more substituents, or together they form 3-12C cycloalkyl or cycloalkenyl, optionally with one or more substituents; R<5>+R<6> = a double bond; R<3>+R<5> = 3-12C cycloalkyl or cycloalkenyl, optionally with one or more substituents; T = CH2, oxygen, CH=CH, ethynyl residue, CH2OCH2, CH2O, OCH2 or CO; n = 0-6. Except for compounds where R<1> phenyl, para-substituted by tert-butyl, chloro or phenyl and R<2>-R<7> are all H. An Independent claim is also included for amines of formula (II) as intermediates for (I).