| 摘要 |
Novel drug targets for the treatment or prevention of arthritis are provided . Screening methods for inhibitors of the plasminogen-activation pathway, such as, for example, antagonists or inhibitors of the urokinase-type okasnubigeb actuvatir (uPA), plasminogen-activator tzpe 1 (PAI-1), the urokinase activat or receptor (uPAR), and plasmin, are used to ientify novel drugs for treating o r preventing the progression of arthritis. Such screening methods, or methods for evaluating whether a drug is useful for treating or preventing arthritis , can also be conducted in animal models described herein. Methods of treating or preventing such diseases are also provided.
|
