| 摘要 |
A method for increasing the proliferative capacity of a cell provides a substance that modulates the activity of a myc repressor and contacts the cell with the substance. The cell is optionally mammalian. Preferably, the mammalian cell is not a stem cell. In another embodiment, the method utilizes a substance that is a peptide, protein, carbohydrate, small molecule, lipid, or natural extract. Also, the myc-repressor activity can be modulated by decreasing the amount of myc-repressor protein in the cell. Also disclosed is a method of delaying aging in a cell that includes administering a pharmaceutical composition with a myc-repressor modulating protein or a portion thereof which is sufficient to promote telomerase expression; and a pharmaceutically acceptable excipient, whereby the increased telomerase increases the length of telomeres in aging tissues. The method may include increasing telomerase expression in non-expressing tissue. In another embodiment, the active protein is pegylated or joined to a molecule to increase its entry into cells. In a preferred embodiment, the substance modulating myc-repressor activity is provided in a topical dosage form. Also disclosed is a composition for delaying aging in a cell, said composition comprising a small molecule which mimics the activities of the myc-repressor modulating protein in promoting expression of telomerase, and a pharmaceutically acceptable excipient.
|
